"World Heath Care Congress Affordable Health Innovations Exhibit and Awards" 7th Annual World Health Care Congress 2010

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Cholera is a disease that is caused by the bacterium, Vibrio cholerae. The bacterium produces enterotoxins that bind to the lining of the small intestine causing exhaustive watery diarrhea. This characteristic of cholera renders many infected patients to be particularly susceptible to severe dehydration and even death within one day, depending on the severity of the case. Cholera is contracted most prevalently through poor drinking sources, usually due to a lack of infrastructure to sustain clean drinking water supplies. Early detection methods are in high demand to prevent cholera outbreaks, which are seasonal in many parts of Africa, Asia, and South America. Researchers at the Department of Chemical Engineering at North Carolina State University are presenting a technology that will facilitate rapid analysis of cholera contamination in water supplies prior to consumption.

The CholerID Program Features:

• Specifically detecting cholera contamination in drinking water samples (before consumption)
• Communicating the contamination to the end user through a distinguishable color change
• Eliminating the need for costly equipment, trained personnel, and a clinician’s diagnosis
• Cost = approx. $4-$5 per chip
• Operates remotely; no power required
• Initial prototyping will involve a model system to assess assay parameters – model detection system includes: goat anti-mouse IgG as bound primary Abs, IgG as model substrate, and gold nanoparticles conjugated to goat anti-mouse secondary Abs

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